In androgen-responsive target tissues such as the skin, scalp, and prostate, the high relative androgenicity of testosterone is dependant on its reduction to dihydrotestosterone (DHT). The 5-alpha reductase enzyme is responsible for this metabolism of testosterone. The concurrent use of a 5-alpha reductase inhibitor such as finasteride or dutasteride will interfere with site-specific potentiation of testosterone action, lowering the tendency of testosterone drugs to produce androgenic side effects. It is important to remember that both anabolic and androgenic effects are mediated via the cytosolic androgen receptor. Complete separation of testosterone’s anabolic and androgenic properties is not possible, even with total 5-alpha reductase inhibition.
For the Testosterone Replacement Therapy candidate generally dosing will fall in the 100mg-200mg per week range and rarely surpassing this amount. However, as frequent injections are necessary most physicians will generally opt for larger ester forms, most commonly Testosterone-Cypionate so the patient only has to inject once per week.
For the performance enhancer the dosing will be much larger and the varying levels will be much wider too but he must necessarily inject frequently as discussed if he is going to maintain stability. Generally the minimal dose when supplementing for performance purposes will be 100mg every other day with 200mg every other day being as high as most will ever go. Yes, you an absolutely take more, there is no set in stone amount but understand such high-end doses can open up the doors to side-effects that you may have wished to remain shut. In elite level competitive sports, especially in elite level bodybuilding it is not uncommon to see doses surpass a 2,000mg per week range but this can be very harsh and there is simply no way such a dosing could ever be recommended in a responsible manner.
As with all cycles, as natural testosterone production will be suppressed, once use is discontinued and responsible use will include breaks Post Cycle Therapy (PCT) is a must in order to aid and speed up the recovery process. This is where Testosterone-Propionate has a bit of advantage over many other forms of testosterone; as a small ester that clears very quickly if your cycle ends with Testosterone-Propionate and there is no other long ester gear present in your system your PCT plan can start almost immediately. Remember, the sooner we start our PCT the better off we’ll be and such rapid PCT application cannot be accomplished with long ester based testosterone. If your cycle ends with Testosterone-Propionate you could reasonably wait 3 days before PCT therapy begins; if it ends with large ester gear you will need to wait approximately 2 weeks.
There have been stories the DEA/FDA may frown upon the dispensing of testosterone propionate instead of testosterone cypionate or enanthate by physicians. The reason given: “it is used more often for performance optimization like growth hormone (GH) and is a red flag”. There are numerous physicians prescribing testosterone propionate in their practices without issue. This may warrant further monitoring for any doctor using testosterone propionate. In my book, I recommend 30-50 mg of Testosterone Propionate injected every other day (EOD) as an excellent option for long term TRT administration.