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Much of the variation in tasting of PTC is associated with polymorphism at the TAS2R38 taste receptor gene.  In humans, there are three SNPs ( single nucleotide polymorphisms ) along the gene that may render its proteins unresponsive.  There is conflicting evidence as to whether the inheritance of this trait is dominant or incompletely dominant .  Any person with a single functional copy of this gene can make the protein and is sensitive to PTC. [ citation needed ] Some studies have shown that homozygous tasters experience a more intense bitterness than people that are heterozygous ; other studies have indicated that another gene may determine taste sensitivity. 
To provide effective cover behind the defensive line, good full-backs are careful not to get caught out of position and must anticipate the opposition's play. Their position behind the backline allows them to see any holes in the defensive line and they either communicate with the backs to close the gaps up or cover the gaps themselves.  The full-back has the most potential for attacking the opposition, especially from a misdirected kick.  If a kick is fielded and there is enough space and support, the full-back may decide to counter-attack by running the ball back towards the opposition.  Due to their kicking skills, in some teams the full-back is also responsible for taking the goal kicks.