Androgens are responsible for the growth spurt of adolescence and for the eventual termination of linear growth, which is brought about by fusion of the epiphyseal growth centers. In children, exogenous androgens accelerate linear growth rates but may cause a disproportionate advancement in bone maturation. Use over long periods may result in fusion of the epiphyseal growth centers and termination of growth process. Androgens have been reported to stimulate the production of red blood cells by enhancing the production of erythropoeitic stimulating factor. During exogenous administration of androgens,Â endogenous testosterone Â release is inhibited through feedback inhibition of pituitary luteinizing hormone (LH).
Yes I have exactly the same symptoms, terrible pain trying to get out of bed in the morning, I used to have to crawl upstairs on all fours. Couldnt sit on an ordinary chair. Suffered about 6 years of this, x-ray showed arthritis. About 6 months ago I discovered my bed was the problem, had tried all sorts, memory foam, air, very firm, soft. etc. After a couple of sleeps on a clapped out old sagging sofa, found much improvement, cut a long story short I have now bought a fully adjustable bed, wish I had done so earlier. i can now sleep all night, get out of it easily and even touch my toes in the morning and getting better. it has the knee break so my legs are bent and raised, i have the head part raised so I am lying in a U shape, its like floating on a cloud, I have a pocket spring mattress on it. I really cant lie on a flat bed any more. I was due to try acupuncture but have cancelled it, I dont even do the excercises that I used to have to do any more. You could just try lying on one of these beds in a store, see how it feels. We spend a third of our lives in bed, no wonder it damages our backs when placed under strain on a flat surface.