The US FDA requires a Risk Evaluation and Mitigation Strategy (REMS) medication guide for Testosterone. For Testosterone Undecanoate, REMS includes elements to assure safe use and implementation system . For additional information: /REMS
US BOXED WARNINGS :
Pulmonary Oil Microembolism (POME) Reactions And Anaphylaxis :
-Serious POME reactions, involving urge to cough, dyspnea, throat tightening, chest pain, dizziness, and syncope; and episodes of anaphylaxis, including life-threatening reactions, have been reported to occur during or immediately after the administration of testosterone undecanoate injection. These reactions can occur after any injection of testosterone undecanoate during the course of therapy, including after the first dose.
-Following each injection of testosterone undecanoate observe patients in the healthcare setting for 30 minutes in order to provide appropriate medical treatment in the event of serious POME reactions or anaphylaxis.
Secondary Exposure To Topical Testosterone :
-Virilization has been reported in children who were secondarily exposed to topical testosterone products.
-Children should avoid contact with unwashed or unclothed application sites in men using testosterone topical.
-Healthcare providers should advise patients to strictly adhere to recommended instructions for use.
Safety and efficacy have not been established in patients younger than 18 years.
Testosterone Enanthate and Testosterone Implant are indicated for delayed puberty in adolescent patients.
Testosterone Cypionate: Safety and efficacy have not been established in patients younger than 12 years.
Consult WARNINGS section for additional precautions.
Tyramine pressor doses were also studied in 11 subjects after extended treatment with Emsam 12 mg per 24 hours. At 30, 60, and 90 days, the mean pressor doses (TYR30) of tyramine administered without food were 95 mg, 72 mg, and 88 mg, respectively. The lowest pressor dose without food was 25 mg in three subjects at day 30 while on Emsam 12 mg per 24 hours. Eight subjects from this study, with a mean tyramine pressor dose of 64 mg at 90 days, were subsequently administered tyramine with food, resulting in a mean pressor dose of 172 mg ( times the mean pressor dose observed without food, p less than ).
Masteron is a Dihydrotestosterone derivative, which prevents it from being aromatized into Estrogen by the aromatase enzyme. This is the enzyme responsible for the conversion of androgens into Estrogen . Furthermore, Masteron has been found to be a proven moderate aromatase inhibitor, serving to disable the aromatase enzyme and reduce Estrogen levels as a result. Therefore, one can expect very solid lean muscle gains without any water retention, and minimal fat gain/retention (provided the user has accompanied their cycle with an appropriate diet). The primary purpose of Masteron among athletes and bodybuilders is to exert its aesthetic e enhancing effects of the removal of subcutaneous water retention (due to its anti-aromatase and anti-estrogen activity). Masteron serves as a very poor mass builder with its moderate anabolic strength rating. It is best utilized stacked with other compounds, as Masteron itself is not that much stronger than Testosterone , and in some cases may be weaker. However, when stacked with Testosterone or any other anabolic steroids, it serves to contribute a couple of amazing features to any cycle that makes the other compounds it is stacked with more powerful.