Propionates 282

Metabolism of propanoate begins with its conversion to propionyl coenzyme A (propionyl-CoA), the usual first step in the metabolism of carboxylic acids. Since propanoic acid has three carbons, propionyl-CoA can directly enter neither beta oxidation nor the citric acid cycles. In most vertebrates, propionyl-CoA is carboxylated to D-methylmalonyl-CoA, which is isomerised to L-methylmalonyl-CoA. A vitamin B 12 -dependent enzyme catalyzes rearrangement of L-methylmalonyl-CoA to succinyl-CoA, which is an intermediate of the citric acid cycle and can be readily incorporated there.

The following are links to news items available on this site relating to the progress of the proposals, the adoption of the controls and subsequent related developments: Progress of the proposals

  • 28 July 2006 - Commission proposes new legislation on food additives, flavourings and enzymes
  • 31 May 2007 - Initial Council discussions on the food improvement agents package (Council discussions)
  • 11 April 2007 - Additives, enzymes and flavourings: MEPs alter the menu (EP Committee discussions)
  • 8 May 2007 - Flavourings and enzymes under supervision (EP Committee discussions)
  • 10 July 2007 - Food additives legislation fit for the 21st century: Parliament updates legislation on food additives (EP First Reading)
  • 19 December 2007 - Council reaches political agreement on food improvement agents package (Council discussions)
  • 10 March 2008 - Food improvement agents: Council adopts Common Position (Council Common Position)
  • 6 May 2008 - Update food additive rules and label azo dyes, says EP Environment Committee (EP Committee discussions)
  • 8 July 2008 - EP Discussions on modernising the rules on food additives and labelling of azo dyes (EP Second Reading)
Adoption of the Regulations

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