Like glycolysis, much of the energy consumed is used in the irreversible steps of the process.
Six high-energy phosphate bonds are consumed: two from GTP and four from ATP. Furthermore, two molecules of NADH are required for the reduction of two molecules of 1,3-bisphosphoglycerate in the reaction catalyzed by glyceraldehyde 3-phosphate dehydrogenase. The oxidation of NADH causes the lack of production of 5 molecules of ATP that are synthesized when the electrons of the reduced coenzyme are used in oxidative phosphorylation.
Also these energetic considerations show that gluconeogenesis is not simply glycolysis in reverse, in which case it would require the consumption of two molecules of ATP, as shown by the overall glycolytic equation.
The short-chain fatty acid butyrate is particularly important for colon health because it is the primary energy source for colonic cells and has anti- carcinogenic as well as anti-inflammatory properties  that are important for keeping colon cells healthy.   Butyrate inhibits the growth and proliferation of tumor cell lines in vitro, induces differentiation of tumor cells, producing a phenotype similar to that of the normal mature cell,  and induces apoptosis or programmed cell death of human colorectal cancer cells.   Butyrate inhibits angiogenesis by inactivating Sp1 transcription factor activity and downregulating VEGF gene expression. 
Tip 21 – Ephedrine Hydrochloride to make ECA Fat Burners – Ciccone Pharma decided to discontinue its ECA Fat Burners. The reason for this is that Eph HCL is now a banned substance all over the world. It is the main ingredient that fuels the narcotics trade and gets used in the manufacturing of Chrystal Meth, Tik and CAT. We are unable to purchase this ingredient anywhere in the world legitimately from any legal API (Active Pharmaceutical Ingredient) manufacturers. In the Far East Eph HCL is regarded as a narcotic and possession of it is a criminal offense. It is not a controlled substance like other pharmaceuticals. It is a banned substance.